A lignan with diverse biological activities
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Gomisin J

Item No. 30213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7S,12aS)-5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene-3,10-diol
CAS Number
66280-25-9
Molecular Formula
C22H28O6
Formula Weight
388.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
215 nm
SMILES
CC1C(C)CC2=C(C(OC)=C(OC)C(O)=C2)C3=C(C=C(O)C(OC)=C3OC)C1
InChi Code
InChI=1S/C22H28O6/c1-11-7-13-9-15(23)19(25-3)21(27-5)17(13)18-14(8-12(11)2)10-16(24)20(26-4)22(18)28-6/h9-12,23-24H,7-8H2,1-6H3
InChi Key
PICOUNAPKDEPCA-UHFFFAOYSA-N
Origin
Plant/Schisandra chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities.1,2 It inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml).1 Gomisin J (20 µM) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells.2 It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 µg/ml.3 Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 µg/ml.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, D.-F., Zhang, S.-X., Xie, J.-X., et al. Anti-AIDS agents—XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg. Med. Chem. 5(8), 1715-1723 (1997).

    2. Oh, S.-Y., Kim, Y.H., Bae, D.S., et al. Anti-inflammatory effects of gomisin J, and Schisandrin C isolated from the fruit of Schisandra chinensis. Biosci. Biotechnol. Biochem. 74(2), 285-291 (2010).

    3. Park, J.Y., Hoi, Y.W., Yun, J.W., et al. Gomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthase. Vascul. Pharmacol. 57(2-4), 124-130 (2012).

    4. Jung, S., Moon, H.-I., Kim, S., et al. Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncol. Rep. 41(1), 711-717 (2019).