A triterpenoid saponin with anti-inflammatory and gastroprotective activities
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Araloside A

Item No. 30219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-α-L-arabinofuranosyl-β-D-glucopyranosiduronic acid
CAS Number
7518-22-1
Synonyms
  • Chikusetsusaponin 4
  • Chikusetsusaponin IV
  • Oleanoside E
Molecular Formula
C47H74O18
Formula Weight
927.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC([C@]2([C@@]3([H])CC(C)(C)CC2)CC[C@]4(C)C3=CC[C@@]5([H])[C@@]4(C)CC[C@]6([H])[C@]5(C)CC[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]8O[C@@H](CO)[C@H](O)[C@H]8O)[C@@H](C(O)=O)O7)C6(C)C)=O)O1
InChi Code
InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-33(55)30(52)28(50)23(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)31(53)35(36(64-40)37(57)58)63-38-32(54)29(51)24(20-49)60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)/t22-,23+,24-,25-,26+,27-,28+,29-,30-,31+,32+,33+,34+,35-,36-,38-,39-,40+,44-,45+,46+,47-/m0/s1
InChi Key
KQSFNXMDCOFFGW-GNDIVNLPSA-N
Origin
Plant/Aralia chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    Araloside A is a triterpenoid saponin that has been found in A. taibaiensis and has anti-inflammatory and gastroprotective effects.1,2 It increases apoptosis of and decreases production of IL-1β and IL-6 in human MH7A rheumatoid arthritis fibroblast-like synoviocytes when used at concentrations ranging from 4 to 16 µM.1 Araloside A (50 and 100 mg/kg) reduces gastric acid secretion and lesion size in rat models of hydrochloric acid and ethanol-, aspirin-, water immersion stress-, or pyloric ligation-induced ulcer formation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ding, Y., Zhao, Q., and Wang, L. Pro-apoptotic and anti-Inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chem. Biol. Interact. 306, 131-137 (2019).

    2. Lee, E.B., Kim, O.J., Kang, S.S., et al. Araloside A, an antiulcer constituent from the root bark of Aralia elata. Biol. Pharm. Bull. 28(3), 523-526 (2005).