A hepatoprotective agent
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Malotilate

Item No. 30266

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1,3-dithiol-2-ylidene)-propanedioic acid, 1,3-bis(1-methylethyl) ester
CAS Number
59937-28-9
Synonyms
  • NKK-105
Molecular Formula
C12H16O4S2
Formula Weight
288.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMSO: 10mg/mLEthanol: 25mg/mLEthanol:PBS (pH 7.2) (1:3): 0.25mg/mL
λmax
223, 362 nm
SMILES
CC(C)OC(/C(C(OC(C)C)=O)=C1SC=CS\1)=O
InChi Code
InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3
InChi Key
YPIQVCUJEKAZCP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Malotilate is a hepatoprotective agent.1 It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury.2 It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zijlstra, F.J., Wilson, J.H., Vermeer, M.A., et al. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Eur. J. Pharmacol. 159(3), 291-295 (1989).

    2. Nokata, M., Katoh, M., and Sugimoto, T. Protective effect of malotilate (Diisopropyl 1,3-dithiol-2-ylidenemalonate) on carbon tetrachloride-induced liver injury in mice and rats. J. Toxicol. Sci. 10(4), 279-288 (1985).

    3. Ryhanen, L., Stenback, F., Ala-Kokko, L., et al. The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat. J. Hepatol. 24(2), 238-245 (1996).