An antiosteoporotic agent
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Bone Growth & Remodeling

Strontium Ranelate

Item No. 30272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid, distrontium salt
CAS Number
135459-87-9
Synonyms
  • S12911
  • S12911-2
Molecular Formula
C12H6N2O8S • 2Sr
Formula Weight
513.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
λmax
214, 234, 324 nm
SMILES
[O-]C(CN(CC([O-])=O)C1=C(C#N)C(CC([O-])=O)=C(C([O-])=O)S1)=O.[Sr+2].[Sr+2]
InChi Code
InChI=1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
InChi Key
XXUZFRDUEGQHOV-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $41

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    50 mg

    $128

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    100 mg

    $196

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    250 mg

    $437

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    Product Description

    Strontium ranelate is an antiosteoporotic agent.1 It inhibits 1,25-dihydroxyvitamin D3-induced increases in the levels of carbonic anhydrase II and the vitronectin receptor, markers of osteoclast differentiation, in isolated chicken bone marrow cells when used at concentrations of 0.1, 0.5, and 1 mM. Pretreatment or continuous treatment of bovine bone slices with strontium ranelate (1 mM) inhibits bone resorption by isolated rat osteoclasts. Strontium ranelate (750 mg/kg per day) decreases osteoclast surface and number, indicating inhibition of bone resorption, but has no effect on the bone formation rate or mineral apposition rate, indicating maintenance of bone formation, in the alveolar bone in adult cynomolgus monkeys.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baron, R., and Tsouderos, Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur. J. Pharmacol. 450(1), 11-17 (2002).

    2. Buehler, J., Chappuis, P., Saffar, J.L., et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone 29(2), 176-179 (2001).