An alkaloid with diverse biological activities
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2,3,5,6-Tetramethylpyrazine

Item No. 30281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1124-11-4
Synonyms
  • Chuanxingzine
  • NSC 36080
  • NSC 46451
  • Tetramethylpyrazine
Molecular Formula
C8H12N2
Formula Weight
136.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
SMILES
CC1=C(C)N=C(C)C(C)=N1
InChi Code
InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
InChi Key
FINHMKGKINIASC-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $36

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    50 g

    $68

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    100 g

    $123

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    500 g

    $535

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    Product Description

    2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.1,2,3 It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.1 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.2 It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shih, Y.H., Wu, S.L., Chiou, W.F., et al. Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture. Neuroreport 13(4), 515-519 (2002).

    2. Pang, P.K., Shan, J.J., and Chiu, K.W. Tetramethylpyrazine, a calcium antagonist. Planta. Med. 62(5), 431-435 (1996).

    3. Chang, Y., Hsiao, G., Chen, S.H., et al. Tetramethylpyrazine suppresses HIF-1α, TNF-α, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats. Acta Pharmacol. Sin. 28(3), 327-333 (2007).