A diterpene with diverse biological activities
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Sclareol

Item No. 30287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,1R,2R,4aS,8aS)-α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-1-naphthalenepropanol
CAS Number
515-03-7
Synonyms
  • (–)-Sclareol
Molecular Formula
C20H36O2
Formula Weight
308.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
SMILES
CC1(C)CCC[C@]2(C)[C@@H](CC[C@@](C)(O)C=C)[C@](C)(O)CC[C@]21[H]
InChi Code
InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1
InChi Key
XVULBTBTFGYVRC-HHUCQEJWSA-N
Origin
Plant/Salvia sclarea
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $40

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    1 g

    $68

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    5 g

    $263

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    10 g

    $488

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    Product Description

    Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.1,2,3 It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).1 Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.2 It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.3 Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Souza, A.B., de Souza, M.G., Moreira, M.A., et al. Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria. Molecules 16(11), 9611-9619 (2011).

    2. Huang, G.-J., Pan, C.-H., and Wu, C.-H. Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model. J. Nat. Prod. 75(1), 54-59 (2012).

    3. Dimas, K., Hatziantgoniou, S., Tseleni, S., et al. Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. Apoptosis 12(4), 685-694 (2007).