An antiparasitic agent
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Clorsulon

Item No. 30288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-6-(1,2,2-trichloroethenyl)-1,3-benzenedisulfonamide
CAS Number
60200-06-8
Synonyms
  • L-631529
  • MK 401
Molecular Formula
C8H8Cl3N3O4S2
Formula Weight
380.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
227, 268, 325 nm
SMILES
NS(C1=CC(S(N)(=O)=O)=C(N)C=C1/C(Cl)=C(Cl)/Cl)(=O)=O
InChi Code
InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
InChi Key
QOVTVIYTBRHADL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Clorsulon is a sulfonamide antiparasitic agent.1 It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 µg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection.2 It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg.3 Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meaney, M., Fairweather, I., Brennan, G.P., et al. Fasciola hepatica: Effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes. Parasitol. Res. 91(3), 238-250 (2003).

    2. Sundlof, S.F., Bliss, E.L., Greiner, E.C., et al. Efficacy of clorsulon for the treatment of experimentally induced infections of fasciola hepatica in goats. Am. J. Vet. Res. 52(1), 111-114 (1991).

    3. Zimmerman, G.L., Wallace, D.H., Schons, D.J., et al. Efficacy of clorsulon against mature naturally acquired fasciola hepatica infections in cattle and sheep. Am. J. Vet. Res. 47(8), 1665-1667 (1986).