An antiallergic agent
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Suplatast (tosylate)

Item No. 30316

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-sulfonium, 4-methylbenzenesulfonate
CAS Number
94055-76-2
Molecular Formula
C16H26NO4S • C7H7O3S
Formula Weight
499.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
223, 253 nm
SMILES
OC(COCC)COC1=CC=C(NC(CC[S+](C)C)=O)C=C1.CC2=CC=C(S([O-])(=O)=O)C=C2
InChi Code
InChI=1S/C16H25NO4S.C7H8O3S/c1-4-20-11-14(18)12-21-15-7-5-13(6-8-15)17-16(19)9-10-22(2)3;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,14,18H,4,9-12H2,1-3H3;2-5H,1H3,(H,8,9,10)
InChi Key
RYVJQEZJUFRANT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Cayman Chemical
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    Product Description

    Suplatast is an antiallergic agent.1,2 It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner.1 Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma.2 It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamaya, H., Basaki, Y., Togawa, M., et al. Down-regulation of Th2 cell-mediated murine peritoneal eosinophilia by antiallergic agents. Life Sci. 56(19), 1647-1654 (1995).

    2. Zhao, G.D., Yokoyama, A., Kohno, N., et al. Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: Inhibition of eosinophilic inflammation and bronchial hyperresponsiveness. Int. Arch. Allergy. Immunol. 121(2), 116-122 (2000).