An alkaloid with diverse biological activities
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Palmatine (chloride)

Item No. 30318

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium, monochloride
CAS Number
10605-02-4
Molecular Formula
C21H22NO4 • Cl
Formula Weight
387.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
229, 267, 350, 433 nm
SMILES
COC1=CC=C2C(C=[N+](CCC3=CC(OC)=C(OC)C=C34)C4=C2)=C1OC.[Cl-]
InChi Code
InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
InChi Key
RLQYRXCUPVKSAW-UHFFFAOYSA-M
Origin
Plant/Fibraurea recisa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities.1,2,3,4,5 It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 µM, respectively).1 Palmatine (20, 40, and 80 µM) reduces Zika virus infection of Vero cells in a concentration-dependent manner.2 In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).3 It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers.4 Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, H.A., Min, B.S., Yokozawa, T., et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol. Pharm. Bull. 32(8), 1433-1438 (2009).

    2. Ho, Y.-J., Lu, J.-W., Huang, Y.-L., et al. Palmatine inhibits Zika virus infection by disrupting virus binding, entry, and stability. Biochem. Biophys. Res. Commun. 518(4), 732-738 (2019).

    3. Zhang, X.-J., Yuan, Z.-W., Qu, C., et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota. Pharmacol. Res. 137, 34-46 (2018).

    4. Wang, L., Wang, X., Zhang, S.-L., et al. Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats. J. Nat. Med. 71(1), 257-264 (2016).

    5. Ma, W.-K., Li, H., Dong, C.-L., et al. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines. Mol. Med. Rep. 14(1), 491-498 (2016).