A ligand for α5 subunit-containing GABAA receptors with nootropic activity
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L-655,708

Item No. 30322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(13aS)-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester
CAS Number
130477-52-0
Molecular Formula
C18H19N3O4
Formula Weight
341.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMF:PBS (pH 7.2) (1:20): Slightly solubleDMSO: 1mg/mL
λmax
248 nm
SMILES
COC1=CC(C(N2[C@@]3([H])CCC2)=O)=C(C=C1)N4C3=C(C(OCC)=O)N=C4
InChi Code
InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
InChi Key
YKYOQIXTECBVBB-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $184

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    25 mg

    $343

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    50 mg

    $627

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    Product Description

    L-655,708 is a ligand for α5 subunit-containing GABAA receptors that has nootropic activity.1 It selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors). L-655,708 (10 nM) increases the amplitude of extracellular post-synaptic potentials (EPSPs) in mouse hippocampal slices. In vivo, L-655,708 (1.5 mg/animal) decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Atack, J.R., Bayley, P.J., Seabrook, G.R., et al. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors. Neuropharmacology 51(6), 1023-1029 (2006).