An anticholinergic agent
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Homatropine (hydrobromide)

Item No. 30359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-hydroxy-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, monohydrobromide
CAS Number
51-56-9
Synonyms
  • (±)-Homatropine
Molecular Formula
C16H21NO3 • HBr
Formula Weight
356.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C(O)C1=CC=CC=C1)O[C@H]2C[C@H](N3C)CC[C@H]3C2.Br
InChi Code
InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
InChi Key
DWSGTFTVBLXELC-RDYJJYPNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $81

    Add
    Product Description

    Homatropine is an anticholinergic agent.1,2 It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 µM.1 Homatropine (1 µM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle.2 It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 µM, respectively).3 Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. George, N., Shiny, P.J., Miriam, J., et al. Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle. Auton. Autacoid Pharmacol. 30(3), 173-177 (2010).

    2. Doggrell, S.A. Effect of antimuscarinic agents on the contractile responses to cholinomimetics in the rat anococcygeus muscle. Br. J. Pharmac. 73(4), 829-835 (1981).

    3. Michal, F., and Penglis, F. Inhibition of serotonin-induced platelet aggregation in relation to thrombus production. J. Pharm. Exp. Ther. 166(2), 276-284 (1969).

    4. Whelan, N.C., Castillo-Alcala, F., and Lizarraga, I. Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats. N.Z. Vet. J. 59(6), 328-331 (2011).