An antiviral
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Nucleozin

Item No. 30363

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-methanone
CAS Number
341001-38-5
Molecular Formula
C21H19ClN4O4
Formula Weight
426.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
ClC1=CC([N+]([O-])=O)=CC=C1N2CCN(C(C3=C(C)ON=C3C4=CC=CC=C4)=O)CC2
InChi Code
InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChi Key
OWXBJAPOSQSWAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Nucleozin is an antiviral inhibitor of influenza nucleoprotein accumulation, preventing it from translocating into the nucleus of host cells.1 It inhibits MDCK cell infection by influenza A and H5N1 (EC50s = 0.069 and 0.33 µM, respectively), as well as a clinical isolate of H3N2 (EC50 = 0.16 µM). Nucleozin reduces the lung viral load and increases the survival rate in a mouse model of influenza H5N1 infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kao, R.Y., Yang, D., Lau, L.-S., et al. Identification of influenza A nucleoprotein as an antiviral target. Nat. Biotechnol. 28(6), 600-605 (2010).