A triterpene with anticancer activity
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Lucidenic Acid A

Item No. 30372

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5α,7β)-7-hydroxy-4,4,14-trimethyl-3,11,15-trioxo-chol-8-en-24-oic acid
CAS Number
95311-94-7
Synonyms
  • Lucideric Acid A
  • Lucidenic Acid α
Molecular Formula
C27H38O6
Formula Weight
458.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: soluble
SMILES
O=C(C[C@]1([H])[C@@H](CCC(O)=O)C)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)[C@](C[C@@H]3O)([H])C(C)(C)C(CC4)=O
InChi Code
InChI=1S/C27H38O6/c1-14(7-8-21(32)33)15-11-20(31)27(6)23-16(28)12-18-24(2,3)19(30)9-10-25(18,4)22(23)17(29)13-26(15,27)5/h14-16,18,28H,7-13H2,1-6H3,(H,32,33)/t14-,15-,16+,18+,25+,26-,27+/m1/s1
InChi Key
INIPQDKLXQHEAJ-NCQSLMINSA-N
Origin
Fungus/Ganoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Lucidenic acid A is a triterpene originally isolated from G. lucidum and has anticancer activity.1,2 It is cytotoxic to HepG2, HepG2 2.2.15', and P388 cancer cells (IC50s = 0.164, 0.205, and 17 nM, respectively). Lucidenic acid A inhibits increases in matrix metalloproteinase-2 (MMP-2) and MMP-9 activity and Matrigel™ invasion induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in HepG2 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, T.-S., Shi, L.-S., and Kuo, S.-C. Cytotoxicity of Ganoderma lucidum triterpenes. J. Nat. Prod. 64(8), 1121-1122 (2001).

    2. Weng, C.-J., Chau, C.-F., Chen, K.-D., et al. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol. Nutr. Food Res. 51(12), 1472-1477 (2007).