A PDE5 inhibitor
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Udenafil

Item No. 30373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-benzenesulfonamide
CAS Number
268203-93-6
Synonyms
  • DA-8159
Molecular Formula
C25H36N6O4S
Formula Weight
516.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 1 mg/ml
λmax
285 nm
SMILES
CCCOC1=CC=C(S(NCCC2N(C)CCC2)(=O)=O)C=C1C(NC3=C4N(C)N=C3CCC)=NC4=O
InChi Code
InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)
InChi Key
IYFNEFQTYQPVOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $396

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    50 mg

    $740

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    Product Description

    Udenafil is an inhibitor of phosphodiesterase 5 (PDE5).1,2,3 In vivo, udenafil (1 and 5 mg/kg) increases lung cGMP levels, attenuates the development of compensatory right ventricular hypertrophy, and reduces pulmonary arterial wall thickening in a rat model of monocrotaline-induced pulmonary hypertension.1 It increases creatine clearance and decreases blood urea nitrogen (BUN) and serum malondialdehyde (MDA) levels in a rat model of renal ischemia-reperfusion injury.2 Udenafil (0.3 and 10 mg/kg) induces penile erections in conscious rabbits and in rabbits with acute spinal cord injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, K.K., Ahn, G.J., Sohn, Y.S., et al. DA-8159, a new PDE5 inhibitor, attenuates the development of compensatory right ventricular hypertrophy in a rat model of pulmonary hypertension. J. Int. Med. Res. 31(6), 517-528 (2003).

    2. Özlülerden, Y., Toktaş, C., Aybek, H., et al. The renoprotective effects of mannitol and udenafil in renal ischemia-reperfusion injury model. Invest. Clin. Urol. 58(4), 289-295 (2017).

    3. Kang, K.K., Ahn, G.J., Ahn, B.O., et al. DA-8159, a new PDE5 inhibitor, induces penile erection in conscious and acute spinal cord injured rabbits. Eur. Urol. 43(6), 689-695 (2003).