A radioprotective agent
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DMA (hydrochloride)

Item No. 30416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-(3,4-dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzo[d]imidazole, trihydrochloride
CAS Number
2095832-33-8
Molecular Formula
C27H28N6O2 • 3HCl
Formula Weight
577.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 15.9 mg/ml
λmax
236, 273, 355 nm
SMILES
CN(CC1)CCN1C(C=C2)=CC3=C2N=C(C4=CC=C(N=C(C5=CC(OC)=C(OC)C=C5)N6)C6=C4)N3.Cl.Cl.Cl
InChi Code
InChI=1S/C27H28N6O2.3ClH/c1-32-10-12-33(13-11-32)19-6-8-21-23(16-19)31-26(29-21)17-4-7-20-22(14-17)30-27(28-20)18-5-9-24(34-2)25(15-18)35-3;;;/h4-9,14-16H,10-13H2,1-3H3,(H,28,30)(H,29,31);3*1H
InChi Key
NJYXXGULZHPSHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

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    10 mg

    $400

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    Cayman Chemical
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    Product Description

    DMA is a bisbenzimidazole radioprotective agent.1,2 In vivo, DMA (300 mg/kg) decreases radiation-induced lethality without affecting radiation-induced tumor regression in an Ehrlich murine spontaneous adenocarcinoma model.1 It prevents radiation-induced damage of intestinal, hepatic, and splenic tissues, increases in splenic malondialdehyde (MDA) production, and decreases in splenic superoxide dismutase (SOD) activity in a B16/F10 murine melanoma model when administered at a dose of 50 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nimesh, H., Tiwari, V., Yang, C., et al. Preclinical evaluation of DMA, a bisbenzimidazole, as radioprotector: Toxicity, pharmacokinetics, and biodistribution studies in Balb/c mice. Mol. Pharmacol. 88(4), 768-778 (2015).

    2. Tiwari, V., Kamran, M.Z., Ranan, A., et al. Akt1/NFκB signaling pathway activation by a small molecule DMA confers radioprotection to intestinal epithelium in xenograft model. Free Rad. Biol. Med. 108, 564-574 (2017).