A heterocyclic building block
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2-Fluoroadenine

Item No. 30421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-fluoro-9H-purin-6-amine
CAS Number
700-49-2
Synonyms
  • F-Ade
  • NSC 27364
Molecular Formula
C5H4FN5
Formula Weight
153.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleEthanol: slightly soluble
λmax
262 nm
SMILES
NC1=C2C(N=CN2)=NC(F)=N1
InChi Code
InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
InChi Key
WKMPTBDYDNUJLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $41

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    500 mg

    $75

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    1 g

    $127

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    Cayman Chemical
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    Product Description

    2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.1 It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Llauger, L., He, H., Kim, J., et al. Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. J. Med. Chem. 48(8), 2892-2905 (2005).

    2. Parker, W.B., Allan, P.W., Shaddix, S.C., et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem. Pharmacol. 55(10), 1673-1681 (1998).