A GPR27 agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Agonists

Research Area

CID-1375606

Item No. 30422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dichloro-N-[4-[(phenylamino)carbonyl]phenyl]-benzamide
CAS Number
313493-80-0
Molecular Formula
C20H14Cl2N2O2
Formula Weight
385.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/ml
λmax
290 nm
SMILES
O=C(C1=CC=C(NC(C2=CC=C(Cl)C=C2Cl)=O)C=C1)NC3=CC=CC=C3
InChi Code
InChI=1S/C20H14Cl2N2O2/c21-14-8-11-17(18(22)12-14)20(26)24-16-9-6-13(7-10-16)19(25)23-15-4-2-1-3-5-15/h1-12H,(H,23,25)(H,24,26)
InChi Key
PFHDXBXPRBQVAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $90

    Add

    10 mg

    $158

    Add

    25 mg

    $349

    Add
    Product Description

    CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase β-arrestin-2 complementation assays, respectively.1 It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce β-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dupuis, N., Laschet, C., Franssen, D., et al. Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Mol. Pharmacol. 91(6), 595-608 (2017).

    2. Ku, G.M., Pappalardo, Z., Luo, C.C., et al. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 8(1), e1002449 (2012).