A GPR27 agonist
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CID-1375606

Item No. 30422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dichloro-N-[4-[(phenylamino)carbonyl]phenyl]-benzamide
CAS Number
313493-80-0
Molecular Formula
C20H14Cl2N2O2
Formula Weight
385.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
290 nm
SMILES
O=C(C1=CC=C(NC(C2=CC=C(Cl)C=C2Cl)=O)C=C1)NC3=CC=CC=C3
InChi Code
InChI=1S/C20H14Cl2N2O2/c21-14-8-11-17(18(22)12-14)20(26)24-16-9-6-13(7-10-16)19(25)23-15-4-2-1-3-5-15/h1-12H,(H,23,25)(H,24,26)
InChi Key
PFHDXBXPRBQVAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $349

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    Product Description

    CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase β-arrestin-2 complementation assays, respectively.1 It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce β-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dupuis, N., Laschet, C., Franssen, D., et al. Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Mol. Pharmacol. 91(6), 595-608 (2017).

    2. Ku, G.M., Pappalardo, Z., Luo, C.C., et al. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 8(1), e1002449 (2012).