A fluorescent neuronal tracer
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DiI

Item No. 30423

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1-propen-1-yl]-3,3-dimethyl-1-octadecyl-3H-indolium, monoperchlorate
CAS Number
41085-99-8
Molecular Formula
C59H97N2 • ClO4
Formula Weight
933.9
Purity
≥98%
Emission
565 nm
Excitation
549 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
519, 551 nm
SMILES
CC(C1=C2C=CC=C1)(C)/C(N2CCCCCCCCCCCCCCCCCC)=C\C=C\C3=[N+](CCCCCCCCCCCCCCCCCC)C4=CC=CC=C4C3(C)C.O=Cl(=O)([O-])=O
InChi Code
InChI=1S/C59H97N2.ClHO4/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-41-50-60-54-46-39-37-44-52(54)58(3,4)56(60)48-43-49-57-59(5,6)53-45-38-40-47-55(53)61(57)51-42-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2;2-1(3,4)5/h37-40,43-49H,7-36,41-42,50-51H2,1-6H3;(H,2,3,4,5)/q+1;/p-1
InChi Key
JVXZRNYCRFIEGV-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $73

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    50 mg

    $128

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    100 mg

    $203

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    Product Description

    DiI is a fluorescent neuronal tracer that labels cell bodies, axons, dendrites, and dendritic spines.1 It has been used as an anterograde tracer to study neuronal development in vivo and as a retrograde tracer to label hippocampal neuronal connections in fixed postmortem brain tissue.1,2 DiI has also been used as a long-term plasma membrane label in live cells.2 It displays excitation/emission maxima of 549/565 nm, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mufson, E.J., Brady, D.R., and Kordower, J.H. Tracing neuronal connections in postmortem human hippocampal complex with the carbocyanine dye DiI. Neurobiol. Aging 11(6), 649-653 (1990).

    2. Honig, M.G., and Hume, R.I. Dil and diO: Versatile fluorescent dyes for neuronal labelling and pathway tracing. Trends Neurosci. 12(9), 333-335 (1989).

    3. Francia, V., Yang, K., Deville, S., et al. Corona composition can affect the mechanisms cells use to internalize nanoparticles. ACS Nano 13(10), 11107-11121 (2019).