A heterocyclic building block

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Product Categories

Product Type

Biochemicals

Synthetic Intermediates & Building Blocks

Research Area

Cancer

Cell Signaling

2-Amino-5-bromo-benzonitrile

Name: 2-Amino-5-bromo-benzonitrile
Brand: -

Item No. 30454

2-Amino-5-bromo-benzonitrile (NSC 263786, CAS Number: 39263-32-6)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

2-amino-5-bromo-benzonitrile

CAS Number

39263-32-6

Synonyms

NSC 263786

Molecular Formula

C₇H₅BrN₂

Formula Weight

197.0

Purity

≥95%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

λ_max

218, 257 nm

SMILES

NC1=C(C#N)C=C(Br)C=C1

InChi Code

InChI=1S/C7H5BrN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2

InChi Key

OATYCBHROMXWJO-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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500 mg

$36

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1 g

$55

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Product Description

2-Amino-5-bromo-benzonitrile is a heterocyclic building block.^1,2 It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Primik, M.F., Göschl, S., Jakupec, M.A., et al. Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligands. Inorg. Chem. 49(23), 11084-11095 (2010).

2. Renhowe, P.A., Pecchi, S., Shafer, C.M., et al. Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A novel class of receptor tyrosine kinase inhibitors. J. Med. Chem. 52(2), 278-292 (2009).

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