BLT₁ Receptor (mouse) Monoclonal Antibody (Clone 7A8)

BLT₁ is a high-affinity G protein-coupled receptor for leukotriene B₄ (LTB₄) with roles in the pathogenesis of various inflammatory and immune diseases.^1,2 It is expressed in most immune cells, including neutrophils, macrophages, eosinophils, and T cells, as well as certain non-immune cells, such as endothelial cells, fibroblasts, and smooth muscle cells.² Binding of LTB₄ to BLT₁ during the onset of inflammation induces early recruitment and activation of neutrophils and inflammatory polarization of macrophages.^2,3 BLT₁ activation also mediates effector T cell recruitment, providing a link between innate and adaptive immunity during T cell-mediated inflammation. Knockdown of Ltbr41, the gene encoding BLT₁, improves glucose tolerance and reduces hyperinsulinemia in a mouse model of high-fat diet-induced obesity.⁴ Ltbr41 knockdown prevents joint immune cell infiltration and the development of arthritis in multiple mouse models of osteoarthritis and rheumatoid arthritis.⁵ Loss of Ltbr41 also increases tumor burden and decreases survival in a mouse model of spontaneous colorectal tumor formation.⁶ Cayman’s BLT₁ Receptor (mouse) Monoclonal Antibody (Clone 7AB) can be used for flow cytometry (FC).

WARNING This product is not for human or veterinary use.

1. Tager, A.M., and Luster, A.D. BLT₁ and BLT₂: The leukotriene B₄ receptors. Prostaglandins, Leukot. Essent. Fatty Acids 69(2-3), 123-134 (2003).

2. He, R., Chen, Y., and Cai, Q. The role of the LTB₄-BLT₁ axis in health and disease. Pharmacol. Res. 158, 104857 (2020).

3. Yokomizo, T., and Shimizu, T. The leukotriene B₄ receptors BLT₁ and BLT₂ as potential therapeutic targets. Immunol. Rev. 317(1), 30-41 (2023).

4. Li, P., Oh, D.Y., Bandyopadhyay, G., et al. LTB₄ promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat. Med. 21(3), 239-247 (2015).

5. Miyabe, Y., Miyabe, C., and Luster, A.D. LTB₄ and BLT₁ in inflammatory arthritis. Semin. Immunol. 33, (2017).

6. Jala, V.R., Bodduluri, S.R., Satpathy, S.R., et al. The yin and yang of leukotriene B₄ mediated inflammation in cancer. Semin. Immunol. 33, (2017).