A heterocyclic building block
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6-Chloro-2-fluoropurine

Item No. 30481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1651-29-2
Synonyms
  • NSC 37363
Molecular Formula
C5H2ClFN4
Formula Weight
172.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
270 nm
SMILES
ClC1=C2C(N=CN2)=NC(F)=N1
InChi Code
InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
InChi Key
UNRIYCIDCQDGQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $41

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    1 g

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    Cayman Chemical
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    Product Description

    6-Chloro-2-fluoropurine is a heterocyclic building block.1,2 It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro.1 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilson, S.C., Atrash, B., Barlow, C., et al. Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. Bioorg. Med. Chem. 19(22), 6949-6965 (2011).

    2. Lee, K., Choi, Y., Gullen, E., et al. Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2',3'-unsaturated L-nucleosides. J. Med. Chem. 42(7), 1320-1328 (1999).