A PEGylated building block
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Boc-NH-PEG3-OH

Item No. 30496

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-carbamic acid, 1,1-dimethylethyl ester
CAS Number
139115-92-7
Molecular Formula
C11H23NO5
Formula Weight
249.3
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(OC(C)(C)C)NCCOCCOCCO
InChi Code
InChI=1S/C11H23NO5/c1-11(2,3)17-10(14)12-4-6-15-8-9-16-7-5-13/h13H,4-9H2,1-3H3,(H,12,14)
InChi Key
FMLOTGGIHAYZLW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $63

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    100 mg

    $118

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    250 mg

    $213

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    500 mg

    $392

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    Cayman Chemical
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    Product Description

    Boc-NH-PEG3-OH is a PEGylated building block that contains a tert-butyloxy carbonyl (Boc) protecting group.1 It has been used as a spacer in biotinylated heterobifunctional cross-linker agents and in near infrared imaging probes for the cytochrome P450 (CYP) isoform CYP1B1, which is expressed in a variety of tumors.1,2 Boc-NH-PEG3-OH has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hatanaka, Y., Hashimoto, M., and Kanaoka, Y. A novel biotinylated heterobifunctional cross-linking reagent bearing an aromatic diazirine. Bioorg. Med. Chem. 2(12), 1367-1373 (1994).

    2. Meng, Q., Wang, Z., Cui, J., et al. Design, synthesis, and biological evaluation of cytochrome P450 1B1 targeted molecular imaging probes for colorectal tumor detection. J. Med. Chem. 61(23), 10901-10909 (2018).

    3. Rerat, V., Dive, G., Cordii, A.A., et al. αvβ3 Integrin-targeting arg-gly-asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J. Med. Chem. 52(22), 7029-7043 (2009).