An HDAC6 inhibitor
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ACY-1083

Item No. 30505

Product Insert (PDF)
Technical Information
Formal Name
2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxy-5-pyrimidinecarboxamide
CAS Number
1708113-43-2
Molecular Formula
C17H18F2N4O2
Formula Weight
348.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1(F)CCC(NC2=NC=C(C(NO)=O)C=N2)(C3=CC=CC=C3)CC1
InChi Code
InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
InChi Key
MRWCVKLVSWYIFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $142

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    5 mg

    $426

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    10 mg

    $710

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    Product Description

    ACY-1083 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 3 nM).1 It increases the levels of acetylated α-tubulin in SK-N-BE(2) cells in a concentration-dependent manner. ACY-1083 (10 mg/kg per day) prevents decreases in mitochondrial oxygen consumption rate (OCR) and mitochondrial motility induced by cisplatin (Item No. 13119) in tibial nerves isolated from mice. It inhibits cisplatin-induced decreases in the mechanical pain threshold in the von Frey test in mice. ACY-1083 prevents decreases in learning and memory induced by doxorubicin (Item No. 15007) in the puzzle box test in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krukowski, K., Ma, J., Golonzhka, O., et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain 158(6), 1126-1137 (2017).

    2. McAlpin, B.R., Mahalingam, R., Singh, A.K., et al. HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics 12(2), 603-619 (2022).