A triterpenoid saponin with neuroprotective activity
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Onjisaponin B

Item No. 30521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,4α)-3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-olean-12-ene-23,28-dioic acid, 28-[O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[O-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-galactopyranosyl] ester
CAS Number
35906-36-6
Synonyms
  • (E)-Senegin III
Molecular Formula
C75H112O35
Formula Weight
1573.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
OC[C@H]1O[C@@H](O[C@@H]2[C@](C(O)=O)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(CO)CC[C@]6(C(O[C@@H]7O[C@H](C)[C@H](OC(/C=C/C8=CC=C(OC)C=C8)=O)[C@H](O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O)[C@H]7O[C@@H]%10O[C@@H](C)[C@H](O[C@@H]%11OC[C@@H](O[C@H]%12[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O%12)[C@H](O)[C@H]%11O)[C@@H](O)[C@H]%10O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)C[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C75H112O35/c1-30-44(81)48(85)53(90)63(99-30)107-59-58(105-43(80)17-12-33-10-13-34(97-9)14-11-33)32(3)101-67(60(59)108-64-56(93)51(88)57(31(2)100-64)106-62-52(89)47(84)40(28-98-62)104-65-54(91)49(86)45(82)38(26-76)102-65)110-69(96)74-21-20-70(4,5)24-36(74)35-15-16-41-71(6)25-37(79)61(109-66-55(92)50(87)46(83)39(27-77)103-66)73(8,68(94)95)42(71)18-19-72(41,7)75(35,29-78)23-22-74/h10-15,17,30-32,36-42,44-67,76-79,81-93H,16,18-29H2,1-9H3,(H,94,95)/b17-12+/t30-,31-,32+,36-,37-,38+,39+,40+,41+,42+,44-,45-,46+,47-,48+,49-,50-,51-,52+,53+,54+,55+,56+,57-,58-,59-,60+,61-,62-,63-,64-,65-,66-,67-,71+,72+,73-,74-,75-/m0/s1
InChi Key
QSTBHNPMHXYCII-KJCIHCEPSA-N
Origin
Plant/Polygala tenuifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Onjisaponin B is a triterpenoid saponin that has been found in P. tenuifolia and has neuroprotective activity.1,2,3 It inhibits glutamate- or serum-starvation-induced neurotoxicity in PC12 cells when used at a concentration of 10 μM.1 Onjisaponin B decreases amyloid-β production in HEK293/APPswe cells (IC50 = 10 μM).2 It reduces spatial learning and memory deficits in the Morris water maze in an APP/PS1 transgenic mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg per day. Onjisaponin B (10 and 20 mg/kg) prevents D-galactose-induced decreases in hippocampal glutathione (GSH) levels and increases in hippocampal malondialdehyde (MDA), IL-1β, IL-6, and TNF-α levels in a rat model of D-galactose-induced aging.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, C., Yang, J., Yu, S., et al. Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia. Planta Med. 74(2), 133-141 (2008).

    2. Li, X., Cui, J., Yu, Y., et al. Traditional Chinese nootropic medicine Radix Polygalae and Its active constituent Onjisaponin B reduce β-amyloid production and improve cognitive impairments. PLoS One 11(3), e0151147 (1986).

    3. Li, G., Yu, J., Zhang, L., et al. Onjisaponin B prevents cognitive impairment in a rat model of D-galactose-induced aging. Biomed. Pharmacother. 99, 113-120 (2018).