A leucine ester and amino acid-containing building block
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H-Leu-OtBu (hydrochloride)

Item No. 30529

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucine, 1,1-dimethylethyl ester, monohydrochloride
CAS Number
2748-02-9
Synonyms
  • L-Leucine t-butyl ester
  • L-Leucine tert-butyl ester
Molecular Formula
C10H21NO2 • HCl
Formula Weight
223.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
213 nm
SMILES
CC(C)C[C@H](N)C(OC(C)(C)C)=O.Cl
InChi Code
InChI=1S/C10H21NO2.ClH/c1-7(2)6-8(11)9(12)13-10(3,4)5;/h7-8H,6,11H2,1-5H3;1H/t8-;/m0./s1
InChi Key
RFUWRXIYTQGFGA-QRPNPIFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $135

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    Product Description

    H-Leu-OtBu is a leucine ester and an amino acid-containing building block.1,2 It increases phosphorylation of the mTORC1 substrate p70 ribosomal S6 kinase (p70S6K) and inhibits L-[14C]leucine uptake into HeLa S3 cells endogenously expressing L-type amino acid transporter 1 (LAT1) when used at concentrations of 0.4 and 1 mM, respectively.2 H-Leu-OtBu has been used in the synthesis of peptide-based ligands of the neurokinin-1 (NK1) receptor.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Millet, R., Goossens, J.-F., Bertrand-Caumont, K., et al. Synthesis and biological evaluation of tripeptide derivatives of Cbz-Gly-Leu-Trp-OBzl(CF3)2 as NK1/NK2 ligands. Lett. Pept. Sci. 6, 255-262 (1999).

    2. Nagamori, S., Wiriyasermkul, P., Okuda, S., et al. Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling. Amino Acids 48(4), 1045-1058 (2016).