An inhibitor of the RAD51-BRCA2 interaction
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Product Type

Biochemicals

Research Area

Cancer
DNA Damage and Repair

CAY10760

Item No. 30532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone
CAS Number
391889-85-3
Molecular Formula
C28H24ClN3O3
Formula Weight
486.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11mg/mLDMF:PBS (pH 7.2) (1:2): 0.3mg/mLDMSO: 10mg/mL
λmax
234 nm
SMILES
O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C4=NN(C(CC)=O)C(C5=CC=C(OC)C=C5)C4
InChi Code
InChI=1S/C28H24ClN3O3/c1-3-25(33)32-24(17-9-12-20(35-2)13-10-17)16-23(31-32)27-26(18-7-5-4-6-8-18)21-15-19(29)11-14-22(21)30-28(27)34/h4-15,24H,3,16H2,1-2H3,(H,30,34)
InChi Key
LAVOKBSCOSIGER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $572

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    25 mg

    $1,073

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    Cayman Chemical
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    Product Description

    CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).1 It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bagnolini, G., Milano, D., Manerba, M., et al. Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib. J. Med. Chem. 63(5), 2588-2619 (2020).