A free radical generator
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Phenazine (methosulfate)

Item No. 30558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methyl-phenazinium, methyl sulfate
CAS Number
299-11-6
Synonyms
  • NSC 34661
Molecular Formula
C13H11N2 • CH3SO4
Formula Weight
306.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
259, 386 nm
SMILES
C[N+]1=C2C(C=CC=C2)=NC3=C1C=CC=C3.[O-]S(=O)(OC)=O
InChi Code
InChI=1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1
InChi Key
RXGJTUSBYWCRBK-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $49

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    5 g

    $167

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    10 g

    $283

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    25 g

    $645

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    Cayman Chemical
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    Product Description

    Phenazine is a free radical generator.1 It has been used as an electron transfer reactant in cell viability assays.2 Phenazine (10 µM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 µM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 µM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, C.-Y., Hu, C.-T., Cheng, C.-C., et al. Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2. Oncotarget 7(10), 11067-11082 (2016).

    2. Hua, A.B., Justiniano, R., Perer, J., et al. Repurposing the electron transfer reactant phenazine methosulfate (PMS) for the apoptotic elimination of malignant melanoma cells through induction of lethal oxidative and mitochondriotoxic stress. Cancers (Basel) 11(5), E590 (2019).