An intermediate in GSH synthesis
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γ-Glu-Cys (ammonium salt)

Item No. 30569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-L-cysteine, ammonium salt
Synonyms
  • γ-Glutamylcysteine
Molecular Formula
C8H14N2O5S • XNH4
Formula Weight
250.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H](N)CCC(N[C@@H](CS)C(O)=O)=O)=O.[NH4+]
InChi Code
InChI=1S/C8H14N2O5S.H3N/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15;/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15);1H3/p+1/t4-,5-;/m0./s1
InChi Key
QTFPRKZNXFUREO-FHAQVOQBSA-O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $69

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    25 mg

    $118

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    50 mg

    $214

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    100 mg

    $363

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    Product Description

    γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1 It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anderson, M.E., and Meister, A. Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesis. Proc. Natl. Acad. Sci. USA 80(3), 707-711 (1983).

    2. Grill, E., Löffler, S., Winnacker, E.-L., et al. Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific γ-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase). Proc. Natl. Acad. Sci. USA 86(18), 6838-6842 (1989).