An inhibitor of MAGL
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CAY10762

Item No. 30576

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-phenylethyl)-1,2-benzisothiazol-3(2H)-one
CAS Number
2514-37-6
Molecular Formula
C15H13NOS
Formula Weight
255.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
227, 247 nm
SMILES
O=C1C2=CC=CC=C2SN1CCC3=CC=CC=C3
InChi Code
InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
InChi Key
VUMUTUGUKRGYGW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $42

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    5 mg

    $183

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    10 mg

    $322

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    Product Description

    CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).1 It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 µM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Castelli, R., Scalvini, L., Vacondio, F., et al. Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines. J. Med. Chem. 63(3), 1261-1280 (2020).