An antiviral compound
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CAY10766

Item No. 30604

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[1-(1,1-dimethylethyl)-4-piperidinyl]-4-(trifluoromethyl)-benzamide
CAS Number
2739990-96-4
Molecular Formula
C17H22ClF3N2O
Formula Weight
362.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 10 mg/ml
SMILES
FC(F)(F)C1=CC=C(C(NC2CCN(C(C)(C)C)CC2)=O)C(Cl)=C1
InChi Code
InChI=1S/C17H22ClF3N2O/c1-16(2,3)23-8-6-12(7-9-23)22-15(24)13-5-4-11(10-14(13)18)17(19,20)21/h4-5,10,12H,6-9H2,1-3H3,(H,22,24)
InChi Key
SLXIKWBDOABMIE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $274

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    10 mg

    $481

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    Cayman Chemical
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    Product Description

    CAY10766 is an antiviral compound.1 It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50 = 0.24 µM). CAY10766 (1 µM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gaisina, I.N., Peet, N.P., Cheng, H., et al. Optimization of 4‑aminopiperidines as inhibitors of influenza A viral entry that are synergistic with oseltamivir. J. Med. Chem. 63(6), 312-3130 (2020).