A saponin with neuroprotective activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tenuifolin

Item No. 30617

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-3β-(β-D-glucopyranosyloxy)-2β,27-dihydroxy-olean-12-ene-23,28-dioic acid
CAS Number
20183-47-5
Synonyms
  • Presenegenin 3-O-glucoside
Molecular Formula
C36H56O12
Formula Weight
680.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
CC1(C)CC[C@@]2(C(O)=O)[C@@](C3=CC[C@@]([C@](C[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5(C)C(O)=O)(C)[C@@]5([H])CC6)([H])[C@]6(C)[C@]3(CO)CC2)([H])C1
InChi Code
InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1
InChi Key
DBJLNNAUDGIUAE-YGIRLYIESA-N
Origin
Plant/Polygalae radix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $95

    Add

    10 mg

    $169

    Add

    25 mg

    $378

    Add
    Product Description

    Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity.1,2 It inhibits β-secretase (BACE) activity by 54.4% when used at a concentration of 10 μg/ml.2 Tenuifolin (2 μg/ml) inhibits secretion of amyloid-β (1-40) (Aβ40) and Aβ42 from COS-7 cells expressing wild-type amyloid precursor protein isoform 695 (APP695 WT) or Swedish mutant APP695 (APP695 Swe). It prevents decreases in PC12 cell viability induced by Aβ (25-35) when used at concentrations of 20 and 40 μg/L.1 Tenuifolin (3 and 9 mg/kg) inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y.-m., Li, Z.-y., Hu, H., et al. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo. Pharmacol. Biochem. Behav. 128, 14-22 (2015).

    2. Lv, J., Jiang, Y., Ruan, Y., et al. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-β secretion in vitro. Acta Physiol. (Oxf.) 196(4), 419-425 (2009).