A saponin with neuroprotective activity
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Tenuifolin

Item No. 30617

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-3β-(β-D-glucopyranosyloxy)-2β,27-dihydroxy-olean-12-ene-23,28-dioic acid
CAS Number
20183-47-5
Synonyms
  • Presenegenin 3-O-glucoside
Molecular Formula
C36H56O12
Formula Weight
680.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
CC1(C)CC[C@@]2(C(O)=O)[C@@](C3=CC[C@@]([C@](C[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5(C)C(O)=O)(C)[C@@]5([H])CC6)([H])[C@]6(C)[C@]3(CO)CC2)([H])C1
InChi Code
InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1
InChi Key
DBJLNNAUDGIUAE-YGIRLYIESA-N
Origin
Plant/Polygalae radix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity.1,2 It inhibits β-secretase (BACE) activity by 54.4% when used at a concentration of 10 μg/ml.2 Tenuifolin (2 μg/ml) inhibits secretion of amyloid-β (1-40) (Aβ40) and Aβ42 from COS-7 cells expressing wild-type amyloid precursor protein isoform 695 (APP695 WT) or Swedish mutant APP695 (APP695 Swe). It prevents decreases in PC12 cell viability induced by Aβ (25-35) when used at concentrations of 20 and 40 μg/L.1 Tenuifolin (3 and 9 mg/kg) inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y.-m., Li, Z.-y., Hu, H., et al. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo. Pharmacol. Biochem. Behav. 128, 14-22 (2015).

    2. Lv, J., Jiang, Y., Ruan, Y., et al. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-β secretion in vitro. Acta Physiol. (Oxf.) 196(4), 419-425 (2009).