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TRV-130 (hydrochloride)

Item No. 30624

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Oliceridine
Technical Information
Formal Name
(9R)-N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-6-oxaspiro[4.5]decane-9-ethanamine, monohydrochloride
CAS Number
1401031-39-7
Molecular Formula
C22H30N2O2S • HCl
Formula Weight
423.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
233, 262 nm
SMILES
COC1=C(CNCC[C@@](C2)(C3=CC=CC=N3)CCOC42CCCC4)SC=C1.Cl
InChi Code
InChI=1S/C22H30N2O2S.ClH/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22;/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3;1H/t21-;/m1./s1
InChi Key
YIIWXYLJZRISQP-ZMBIFBSDSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    TRV-130 (hydrochloride) (Item No. 30624) is an analytical reference standard categorized as an opioid.1 TRV-130 has potential for abuse.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DeWire, S.M., Yamashita, D.S., Rominger, D.H., et al. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J. Pharmacol. Exp. Ther. 344(3), 708-717 (2013).

    2. Negus, S.S., and Freeman, K.B. Abuse potential of biased mu opioid receptor agonists. Trends Pharamacol. Sci. 39(11), 916-919 (2018).

    Product Citations

    Stahl, E.L., Schmid, C.L., Acevedo-Canabal, A., et al. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc. Natl. Acad. Sci. USA 118(48), e2102178118 (2021).