An inhibitor of GlyT1
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ALX 5407 (hydrochloride)

Item No. 30626

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3R)-3-([1,1′-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methyl-glycine, monohydrochloride
CAS Number
200006-08-2
Molecular Formula
C24H24FNO3 • HCl
Formula Weight
429.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
SMILES
FC(C=C1)=CC=C1[C@@H](CCN(C)CC(O)=O)OC(C=C2)=CC=C2C3=CC=CC=C3.Cl
InChi Code
InChI=1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
InChi Key
RPDGSZCYSJWQEE-GNAFDRTKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    25 mg

    $502

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    Product Description

    ALX 5407 is an inhibitor of glycine transporter 1 (GlyT1; IC50 = 3 nM).1 It is selective for GlyT1 over GlyT2 (IC50 = >10 µM), as well as over NMDA receptors and the inhibitory glycine receptor at 100 µM. ALX 5407 (10 mg/kg) increases prefrontal cortical levels of glycine in rats. It also reverses MK-801-induced persistent latent inhibition in a mouse model of schizophrenia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Atkinson, B.N., Bell, S.C., De Vivo, M., et al. ALX 5407: A potent, selective inhibitor of the hGlyT1 glycine transporter. Mol. Pharmacol. 60(6), 1414-1420 (2001).

    2. Lipina, T., Labrie, V., Weiner, I., et al. Modulators of the glycine site on NMDA receptors, ᴅ-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology (Berl) 179(1), 54-67 (2005).