A COX inhibitor and the active metabolite of nepafenac
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Pro-drug Form(s)
23700Nepafenac
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Amfenac (sodium salt hydrate)

Item No. 30627

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-3-benzoyl-benzeneacetic acid, monosodium salt, monohydrate
CAS Number
61618-27-7
Molecular Formula
C15H12NO3 • Na [H2O]
Formula Weight
295.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 10mg/mLEthanol: 5mg/mLPBS (pH 7.2): 5mg/mL
λmax
238 nm
SMILES
NC1=C(C(C2=CC=CC=C2)=O)C=CC=C1CC([O-])=O.[Na+].O
InChi Code
InChI=1S/C15H13NO3.Na.H2O/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10;;/h1-8H,9,16H2,(H,17,18);;1H2/q;+1;/p-1
InChi Key
QZNJPJDUBTYMRS-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $36

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    5 g

    $128

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    10 g

    $236

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    25 g

    $502

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    Product Description

    Amfenac is an inhibitor of COX-1 and COX-2 (IC50s =15.3 and 20.4 nM, respectively, for the recombinant human enzymes) and the active metabolite of the non-steroidal anti-inflammatory drug (NSAID) nepafenac (Item No. 23700).1 Amfenac (150 nM) reduces the migration of 92.1 uveal melanoma cells, as well as proliferation of the same cells when used in combination with ranibizumab.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kida, T., Kozai, S., Takahashi, H., et al. Pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs in retinochoroidal tissues in rabbits. PLoS One 9(5), e96481 (2014).

    2. Bravo-Filho, V., Logan, P., Zoroquiain, P., et al. Effects of ranibizumab and amfenac on the functional abilities and radiosensitivity of uveal melanoma cells. Arq. Bras. Oftalmol. 82(1), 38-44 (2019).