A triterpene saponin with antiviral and antioxidant activities
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Hederasaponin B

Item No. 30641

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-olean-12-en-28-oic acid, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester
CAS Number
36284-77-2
Synonyms
  • Hederacoside B
  • Hederagenin B
Molecular Formula
C59H96O25
Formula Weight
1205.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC1(C)CC[C@]2(C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H](O)[C@H]4O)O3)=O)CC[C@@]6(C)[C@]([C@]7([H])CC=C6[C@]2([H])C1)(C)CC[C@@]([C@]7(C)CC8)([H])C(C)(C)[C@H]8O[C@@H]9OC[C@H](O)[C@H](O)[C@H]9O[C@H]%10[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10
InChi Code
InChI=1S/C59H96O25/c1-24-34(62)38(66)42(70)49(77-24)82-46-29(21-60)79-48(45(73)41(46)69)76-23-30-37(65)40(68)44(72)51(80-30)84-53(74)59-18-16-54(3,4)20-27(59)26-10-11-32-56(7)14-13-33(55(5,6)31(56)12-15-58(32,9)57(26,8)17-19-59)81-52-47(36(64)28(61)22-75-52)83-50-43(71)39(67)35(63)25(2)78-50/h10,24-25,27-52,60-73H,11-23H2,1-9H3/t24-,25-,27-,28-,29+,30+,31-,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,56-,57+,58+,59-/m0/s1
InChi Key
NVSLBOBPSCMMSO-BVLVEXITSA-N
Origin
Plant/Rhizoma Anemones Raddeanae
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $762

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    Product Description

    Hederasaponin B is a triterpene saponin that has been found in H. helix and has antiviral and antioxidant activities.1,2 It inhibits the cytopathic effect induced by the enterovirus 71 (EV71) genotypes C3 and C4a (EC50s = 24.77 and 41.77 µg/ml, respectively), as well as reduces expression of the viral structural capsid protein VP2, in Vero cells.1 Hederasaponin B (100, 150, and 200 µg/ml) inhibits superoxide generation in human neutrophils.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Song, J., Yeo, S.-G., Hong, E.-H., et al. Antiviral activity of hederasaponin B from Hedera helix against enterovirus 71 subgenotypes C3 and C4a. Biomol. Ther. (Seoul) 22(1), 41-46 (2014).

    2. Chen, X., Lu, J., He, W., et al. Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana. Fitoterapia 80(2), 105-111 (2009).