Lycorine

Lycorine is an alkaloid that has been found in Amaryllidaceae and has diverse biological activities.^1,2,3,4 It is active against P. falciparum (IC₅₀ = 1.026 µg/ml).¹ Lycorine inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) viral infection in Vero cells (EC₅₀ = 15.7 µM).² It inhibits migration of A549 non-small cell lung cancer (NSCLC) and U373 MG glioblastoma cells when used at a concentration of 5 µM.³ Lycorine (0.4 mg/kg) increases survival and reduces virus-induced paralysis in a mouse model of enterovirus 71 infection.⁴

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1. Sener, B., Orhan, I., and Satayavivad, J. Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae. Phytother. Res. 17(10), 1220-1223 (2003).

2. Li, S.-Y., Chen, C., Zhang, H.-Q., et al. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res. 67(1), 18-23 (2005).

3. Lamoral-Theys, D., Andolfi, A., Van Goietsenoven, G., et al. Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: An investigation of structure-activity relationship and mechanistic insight. J. Med. Chem. 52(20), 6244-6256 (2009).

4. Liu, J., Yang, Y., Xu, Y., et al. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication. Virol. J. 8, 483 (2011).