An antimalarial agent
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Tafenoquine

Item No. 30673

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine
CAS Number
106635-80-7
Synonyms
  • WR 238605
Molecular Formula
C24H28F3N3O3
Formula Weight
463.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
CC1=CC(OC)=NC2=C1C(OC3=CC=CC(C(F)(F)F)=C3)=C(OC)C=C2NC(CCCN)C
InChi Code
InChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3
InChi Key
LBHLFPGPEGDCJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

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    25 mg

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    50 mg

    $416

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    Cayman Chemical
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    Product Description

    Tafenoquine is an aminoquinoline antimalarial agent.1 It is active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml). Tafenoquine (25 or 50 mg/kg) inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice.2 It also suppresses parasitemia in a hamster model of B. microti infection when administered at doses ranging from 3.25 to 52 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohrt, C., Willingmyre, G.D., Lee, P., et al. Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 46(8), 2518-2524 (2002).

    2. Coleman, R.E. Sporontocidal activity of the antimalarial WR-238605 against Plasmodium berghei ANKA in Anopheles stephensi. Am. J. Trop. Med. Hyg. 42(3), 196-205 (1990).

    3. Marley, S.E., Eberhard, M.L., Steurer, F.J., et al. Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster model. Antimicrob. Agents Chemother. 41(1), 91-94 (1997).