A prodrug form of cycloguanil
Related Products
Active Metabolite(s)
16861Cycloguanil (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Proguanil

Item No. 30675

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-N′-(1-methylethyl)-imidodicarbonimidic diamide
CAS Number
500-92-5
Synonyms
  • Chlorguanide
  • Chloroguanide
Molecular Formula
C11H16ClN5
Formula Weight
253.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.05 mg/mlEthanol: 1 mg/ml
λmax
259 nm
SMILES
ClC1=CC=C(NC(NC(NC(C)C)=N)=N)C=C1
InChi Code
InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
InChi Key
SSOLNOMRVKKSON-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $53

    Add

    10 mg

    $98

    Add

    25 mg

    $231

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).1 Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.2 It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.3 Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Birkett, D.J., Rees, D., Anderson, T., et al. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. Br. J. Clin. Pharmacol. 37(5), 413-420 (1994).

    2. Thapar, M.M., Gupta, S., Spindler, C., et al. Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro. Trans. R. Soc. Trop. Med. Hyg. 97(3), 331-337 (2003).

    3. Black, R.H., and Ray, A.P. Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using Plasmodium berghei in white mice. Ann. Trop. Med. Parasitol. 71(2), 131-139 (1977).