An antimalarial agent
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Arterolane

Item No. 30676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cis-N-(2-amino-2-methylpropyl)-dispiro[cyclohexane-1,3′-[1,2,4]trioxolane-5′,2′′-tricyclo[3.3.1.13,7]decane]-4-acetamide
CAS Number
664338-39-0
Synonyms
  • OZ277
  • RBx-11160
Molecular Formula
C22H36N2O4
Formula Weight
392.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(C[C@H]1CC[C@]2(OC3([C@@]4([H])C[C@H]5C[C@]3([H])C[C@@H](C4)C5)OO2)CC1)NCC(C)(C)N
InChi Code
InChI=1S/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)/t14-,15-,16+,17-,18+,21+,22?
InChi Key
VXYZBLXGCYNIHP-PLZCFGKPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Arterolane is an antimalarial agent.1 It is active against 10 strains of P. falciparum in vitro, including chloroquine- and pyrimethamine-resistant strains, with IC50 values ranging from 0.43 to 1.6 ng/ml. Arterolane (10 mg/kg per day for three days) is curative in 67% of mice in a model of P. berghei infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vennerstrom, J.L., Arbe-Barnes, S., Brun, R., et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430(7002), 900-904 (2004).