An antimalarial agent
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DSM 265

Item No. 30680

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(OC-6-21)-[4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-sulfur
CAS Number
1282041-94-4
Molecular Formula
C14H12F7N5S
Formula Weight
415.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CC1=NC2=NC(C(F)(F)C)=NN2C(NC3=CC=C(C=C3)S(F)(F)(F)(F)F)=C1
InChi Code
InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3
InChi Key
OIZSVTOIBNSVOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    DSM 265 is an antimalarial agent and inhibitor of P. falciparum and P. vivax dihydroorotate dehydrogenase (DHODH; IC50s = 8.9 and 27 nM, respectively).1 It is selective for P. falciparum and P. vivax DHODH over human, rabbit, pig, and monkey DHODH (IC50s = >41 µg/ml) but does inhibit P. cynomolgi, dog, mouse, and rat DHODH (IC50s = 0.005, 11, 1.1, and 0.82 µg/ml, respectively).2 DSM 265 inhibits the growth of the P. falciparum strain 3D7 with an EC50 value of 4.3 nM.1 It also reduces blood parasitemia in mice (ED90 = 1.5 mg/kg twice per day).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kokkonda, S., Deng, X., White, K.L., et al. Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity. J. Med. Chem. 59(11), 5416-5431 (2016).

    2. Phillips, M.A., Lotharius, J., Marsh, K., et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci. Transl. Med. 7(296), 296ra111 (2015).