An AMPA receptor antagonist
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YM-90K (hydrochloride hydrate)

Item No. 30683

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione, monohydrochloride, hydrate
Molecular Formula
C11H7N5O4 • HCl [XH2O]
Formula Weight
309.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
SMILES
O=C(N1)C(NC(C1=C2)=CC([N+]([O-])=O)=C2N3C=NC=C3)=O.Cl.O
InChi Code
InChI=1S/C11H7N5O4.ClH.H2O/c17-10-11(18)14-7-4-9(16(19)20)8(3-6(7)13-10)15-2-1-12-5-15;;/h1-5H,(H,13,17)(H,14,18);1H;1H2
InChi Key
NPEZQTYOSAYJTA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $198

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    10 mg

    $329

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    25 mg

    $655

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    Product Description

    YM-90K is an AMPA receptor antagonist (Ki = 0.084 μM in a radioligand binding assay using rat brain membranes).1 It is selective for AMPA over kainate, NMDA-sensitive glutamate, and strychnine-insensitive glycine receptors (Kis = 2.2, >100, and 37 μM, respectively). Intrastriatal administration of YM-90K inhibits AMPA-induced decreases in choline acetyltransferase (ChAT) activity in rat striatum ex vivo in a dose-dependent manner. It inhibits audiogenic seizures in susceptible DBA/2 mice with a minimum effective dose of 3 mg/kg when administered intraperitoneally. Intravenous infusion of YM-90K (20 mg/kg per hour for 4 hours) reduces infarct size in a rat model of focal cerebral ischemia induced by thrombotic middle cerebral artery occlusion (MCAO) in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohmori, J., Sakamoto, S., Kubota, H., et al. 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: Structure-activity relationships for the AMPA-type non-NMDA receptor. J. Med. Chem. 37(4), 467-475 (1994).

    2. Umemura, K., Shimakura, A., and Nakashima, M. Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773(1-2), 61-65 (1997).