A β-lactam antibiotic
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Mezlocillin (sodium salt)

Item No. 30691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
CAS Number
42057-22-7
Molecular Formula
C21H24N5O8S2 • Na
Formula Weight
561.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H](C1=CC=CC=C1)NC(N2CCN(S(C)(=O)=O)C2=O)=O)N[C@@H]3C(N4[C@]3([H])SC(C)(C)[C@@H]4C([O-])=O)=O.[Na+]
InChi Code
InChI=1S/C21H25N5O8S2.Na/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34;/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30);/q;+1/p-1/t12-,13-,14+,17-;/m1./s1
InChi Key
GTGQRSIMEUWHPA-ZBJAFUORSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Mezlocillin is a β-lactam antibiotic and derivative of ampicillin (Item No. 14417).1,2 It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 µg/ml, respectively).2 Mezlocillin (32 µg/ml) is also active against 10 strains of S. faecalis.1 In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg.2 Formulations containing mezlocillin have been used in the treatment of various bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fass, R.J., and Wright, C.A. Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits. Antimicrob. Agents Chemother. 25(4), 408-410 (1983).

    2. Chandrasekar, P.H., Rolston, K.V.I., Chokkavelu, C., et al. Comparative efficacy of four antibiotics in anaerobic pulmonary infection. An experimental model in rabbits. Chemotherapy 30(5), 331-336 (1984).