A peptide agonist of GHS-R
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Hexarelin

Item No. 30716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
CAS Number
140703-51-1
Synonyms
  • Examorelin
  • H-2-Me-WAWFK
  • His-2-Me-Trp-Ala-Trp-Phe-Lys-NH2
  • His-(D)-Mrp-Ala-Trp-(D)-Phe-Lys-NH2
Molecular Formula
C47H58N12O6
Formula Weight
887.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
221 nm
SMILES
O=C(N[C@H](CC1=C(C)NC2=C1C=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)[C@@H](N)CC6=CN=CN6
InChi Code
InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2,1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59,65)/t28-,35-,38-,39+,40-,41+/m0/s1
InChi Key
RVWNMGKSNGWLOL-GIIHNPQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $392

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    10 mg

    $696

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    Product Description

    Hexarelin is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R).1,2 It selectively binds to GHS-R over CD36 (IC50s = 15.9 and 2,080 nM, respectively).1 Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats.2 It also improves left ventricular function and reduces fibrosis in a mouse model of myocardial ischemia induced by transient ligation of the left descending coronary artery (LAD) when administered at a dose of 0.3 mg/kg per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Proulx, C., Picard, É., Boeglin, D., et al. Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a. J. Med. Chem. 55(14), 502-511 (2012).

    2. Guerlavais, V., Boeglin, D., Mousseaux, D., et al. New active series of growth hormone secretagogues. J. Med. Chem. 46(7), 1191-1203 (2003).

    3. McDonald, H., Peart, J., Kurniawan, N.D., et al. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion. Biomed. Pharmacother. 127, 110165 (2020).