A Mat2A inhibitor
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PF-9366

Item No. 30782

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine
CAS Number
72882-78-1
Molecular Formula
C20H19ClN4
Formula Weight
350.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlEthanol: 2 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
233 nm
SMILES
ClC1=CC=C2C(C(C3=CC=CC=C3)=CC4=NN=C(CCN(C)C)N42)=C1
InChi Code
InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3
InChi Key
LYLASWLQCMKZAT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $349

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    Cayman Chemical
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    Product Description

    PF-9366 is an inhibitor of methionine adenosyltransferase 2A (Mat2A; IC50 = 420 nM for S-adenosyl-L-methionine (SAM) production in an enzyme assay).1 It is selective for Mat2A over a panel of neurotransmitter transporters, phosphodiesterases, ion channels, and G protein-coupled receptors, as well as a panel of 39 kinases at 10 µM. PF-9366 inhibits SAM production in H520 lung carcinoma cells (IC50 = 1.2 µM) and Huh7 hepatocellular carcinoma cells (IC50 = 225 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Quinlan, C.L., Kaiser, S.E., Bolaños, B., et al. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat. Chem. Biol. 13(7), 785-792 (2017).