Idronoxil

Idronoxil is a phenol and derivative of genistein (Item No. 10005167) that has been found in B. tournefortii and has anticancer activity.^1,2,3 It reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells, but not non-cancerous ovarian surface epithelial (OSE) cells, when used at a concentration of 10 µg/ml.² Idronoxil (1 µg/ml) reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells. In vivo, idronoxil (50 and 75 mg/kg) increases latency to tumor formation and reduces tumor multiplicity in a rat model of mammary carcinogenesis induced by dimethylbenz[a]anthracene (DMBA).³

WARNING This product is not for human or veterinary use.

1. Rahmani, R., Bouajila, J., Jouaidi, M., et al. African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties. J. Food Sci. 85(6), 1856-1871 (2020).

2. Kamsteeg, M., Rutherford, T., Sapi, E., et al. Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 22(17), 2611-2620 (2003).

3. Constantinou, A.I., Mehta, R., and Husband, A. Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley rats. Eur. J. Cancer 39(7), 1012-1018 (2004).