A derivative of thymidine and synthetic precursor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5′-O-(4,4′-Dimethoxytrityl)thymidine

Item No. 30802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-O-[bis(4-methoxyphenyl)phenylmethyl]-thymidine
CAS Number
40615-39-2
Synonyms
  • DMT-T
  • DMTrT
Molecular Formula
C31H32N2O7
Formula Weight
544.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4O[C@](N5C(NC(C(C)=C5)=O)=O)([H])C[C@@H]4O
InChi Code
InChI=1S/C31H32N2O7/c1-20-18-33(30(36)32-29(20)35)28-17-26(34)27(40-28)19-39-31(21-7-5-4-6-8-21,22-9-13-24(37-2)14-10-22)23-11-15-25(38-3)16-12-23/h4-16,18,26-28,34H,17,19H2,1-3H3,(H,32,35,36)/t26-,27+,28+/m0/s1
InChi Key
UBTJZUKVKGZHAD-UPRLRBBYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $36

    Add

    100 mg

    $61

    Add

    250 mg

    $135

    Add
    Product Description

    5'-O-(4,4'-Dimethoxytitryl)thymidine is a derivative of thymidine containing a dimethoxytrityl protecting group.1 It has been used as a precursor in the synthesis of oligo-2’-deoxyribonucleotides and phosphoramidate derivatives.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shelkovnikov, V.V., Loskutov, V.A., Vasil'ev, E.V., et al. New acid photogenerators based on thioxanthen-9-one sulfonium derivatives for detritylation in the oligonucleotide synthesis. Russ. Chem. Bull. 60(3), 561-569 (2011).

    2. Kungurtsev, V., Laakkonen, J., Molina, A.G., et al. Solution-phase synthesis of short oligo-2-deoxyribonucleotides by using clustered nucleosides as a soluble support. Eur. J. Org. Chem. 29, 6687-6693 (2013).

    3. Lin, C., Fu, H., Tu, G., et al. Synthesis of dinucleotide thiophosphoramidates as anti-HIV new prodrugs. Cheminform 35(13), 1989-1994 (2003).

    4. Kungurtsev, V., Lönnberg, H., and Virta, P. Synthesis of protected 2'-O-deoxyribonucleotides on a precipitative soluble support: A useful procedure for the preparation of trimer phosphoramidites. RSC Adv. 6(107), 105428-105432 (2016).