A metalloporphyrin
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Mn(III) Protoporphyrin IX Chloride

Item No. 30808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-manganate(2-), dihydrogen
CAS Number
120389-54-0
Synonyms
  • Manganese(III) Protoporphyrin IX Chloride
Molecular Formula
C34H30ClMnN4O4 • 2H
Formula Weight
651.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 5 mg/ml2 M NaOH: 10 mg/ml
λmax
230, 371, 463, 551 nm
SMILES
[Cl-][Mn+3]1([N](C2=C3)=C(C(C=C)=C2C)C=C4C(C)=C5CCC([O-])=O)([N-]6C3=C7C=C)[N-]4C5=CC(C(CCC([O-])=O)=C8C)=[N]1C8=CC6=C7C.[H+].[H+]
InChi Code
InChI=1S/C34H34N4O4.ClH.Mn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
InChi Key
BJLYQWVPQKTSMI-HXFTUNQESA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    250 mg

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    Product Description

    Mn(III) protoporphyrin IX chloride is a metalloporphyrin.1 It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 µM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro.2 It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cable, E.E., Pepe, J.A., Karamitsios, N.C., et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94(2), 649-654 (1994).

    2. Pan, D., Caruthers, S.D., Hu, G., et al. Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets. J. Am. Chem. Soc. 130(29), 9186-9187 (2008).

    3. Ryabova, E.S., and Nordlander, E. Synthesis and reactivity studies of a manganese “microperoxidase” containing b-type heme. Dalton Trans. 7, 1228-1233 (2005).