An orally bioavailable iron chelator
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Product Categories

Product Type

Biochemicals
Metal Chelators

Research Area

Cell Biology
Cell Death
Ferroptosis

CN128

Item No. 30833

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydroxy-1-[(1R)-1-(hydroxymethyl)-2-phenylethyl]-2-methyl-pyridinium
CAS Number
2457170-98-6
Synonyms
  • R-CN128
Molecular Formula
C15H18NO3
Formula Weight
260.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: 5 mg/mlMethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
287 nm
SMILES
OC1=C(O)C(C)=[N+]([C@@H](CO)CC2=CC=CC=C2)C=C1
InChi Code
InChI=1S/C15H17NO3/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12/h2-8,13,17,19H,9-10H2,1H3/p+1/t13-/m1/s1
InChi Key
FAYRGKKCBATAET-CYBMUJFWSA-O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $306

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    Product Description

    CN128 is an orally bioavailable iron chelator.1 It contains a side chain hydroxy group that acts as an alternate sacrificial glucuronidation site to alleviate metabolic inactivation at the 3-hydroxy group. CN128 increases iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload when administered at doses of 150 and 450 µmol/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, W., Yuan, X., Li, Z., et al. CN128: A new orally active hydroxypyridinone iron chelator. J. Med. Chem. 63(8), 4215-4226 (2020).