A corticosteroid
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Deoxycorticosterone Acetate

Item No. 30856

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-pregn-4-ene-3,20-dione
CAS Number
56-47-3
Synonyms
  • DOCA
Molecular Formula
C23H32O4
Formula Weight
372.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
240 nm
SMILES
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(COC(C)=O)=O)=C1
InChi Code
InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
InChi Key
VPGRYOFKCNULNK-ACXQXYJUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Deoxycorticosterone acetate (DOCA) is a corticosteroid.1 It is an acetylated form of deoxycorticosterone (11-deoxy corticosterone; Item No. 22916). DOCA, in combination with saline via the drinking water, has commonly been used in rodents as a model of salt-sensitive hypertension, characterized by increases in sympathetic nervous system activity, imbalances in the renin-angiotensin system (RAS), and cardiac remodeling.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vinson, G.P. The mislabelling of deoxycorticosterone: Making sense of corticosteroid structure and function. J. Endocrinol. 211(1), 3-16 (2011).

    2. Basting, T., and Lazartigues, E. DOCA-salt hypertension: An update. Curr. Hypertens. Rep. 19(4), 32 (2017).

    3. Lee, L.-K., Kim, M.-Y., Kim, J.-H., et al. A review of deoxycorticosterone acetate-salt hypertension and its relevance for cardiovascular physiotherapy research. J. Phys. Ther. Sci. 27(1), 303-307 (2015).