A coumarin with diverse biological activities
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Isomer(s)
296034-Methylumbelliferone
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7-Methoxycoumarin

Item No. 30857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-methoxy-2H-1-benzopyran-2-one
CAS Number
531-59-9
Synonyms
  • Ayapanin
  • Gerniarin
  • Herniarin
  • Methylumbelliferone
  • NSC 404559
Molecular Formula
C10H8O3
Formula Weight
176.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:4): 0.2mg/mLEthanol: 5mg/mL
λmax
217, 323 nm
SMILES
COC1=CC=C(C=CC(O2)=O)C2=C1
InChi Code
InChI=1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3
InChi Key
LIIALPBMIOVAHH-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $54

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    Cayman Chemical
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    Product Description

    7-Methoxycoumarin is a coumarin that has been found in S. oblongifolia and has diverse biological activities.1,2,3 It reduces the release of prostaglandin E2 (PGE2; Item No. 14010) and leukotriene C4 (LTC4; Item No. 20210) induced by A23187 (Item No. 110160) in isolated mouse peritoneal macrophages.1 7-Methyoxycoumarin is active against S. aureus, S. epidermidis, B. subtilis, S. lutea, and V. cholera (MICs = 0.5, 0.75, 0.75, 0.75, and 0.5 mg/ml, respectively).2 In vivo, 7-methoxycoumarin (3.5 and 7 mg/kg) reduces formalin-induced paw licking and biting responses in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Silván, A.M., Abad, M.J., Bermejo, P., et al. Antiinflammatory activity of coumarins from Santolina oblongifolia. J. Nat. Prod. 59(12), 1183-1185 (1996).

    2. Canales-Martínez, M., Hernández-Delgado, T., Flores-Ortiz, C., et al. Antimicrobial activity of Alternanthera caracasana. Pharm. Biol. 43(4), 305-307 (2005).

    3. Cheriyan, B.V., Sr., Kadhirvelu, P., Sr., Nadipelly, J., Jr., et al. Anti-nociceptive effect of 7-methoxy coumarin from Eupatorium triplinerve vahl (Asteraceae). Pharmacogn. Mag. 13(49), 81-84 (2017).